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Dr. Alexander Kornienko - Professor


Dr. Alexander Kornienko

Contact Information

Office:  CHEM 319

Phone:  (512) 245-3632

Fax:  (512) 245-2374

email:  a_k76@txstate.edu

Educational Background

  • B.S in Chemical Engineering, Mendeleev University, Moscow, Russia, 1994
  • Ph.D. in Chemistry, Tufts University, Boston, USA, 1999
  • Postdoctoral Fellow, Université de Montréal, Canada, 2001

Areas of Interest

  • Synthetic Organic Chemistry (total synthesis and methodology)
  • Chemical Biology (focus on cancer signaling and death pathways)
  • Medicinal Chemistry (rational drug design and library screening)
  • Natural Product Chemistry (isolation, structure elucidation and analogue synthesis)

Related Web Sites

Kornienko CV

 

 

 


Research in the Kornienko Group

The unifying theme of Kornienko’s research projects is the discovery of novel synthetic organic chemistry and its utilization for anticancer drug discovery. For example, in one of the ongoing projects we discovered a new multicomponent reaction allowing for the construction of a pyrrole ring and applied it to the first general total synthesis of marine alkaloid rigidins (A below). The synthesis facilitated further synthetic and biological studies, which led to the discovery of a new anticancer scaffold based on the hypoxanthine core structure (B). These new agents are active at nanomolar concentrations against melanoma and glioblastoma, cancers with dismal clinical prognoses, and can now be made through a 4-component reaction in one step from commercially available reagents (B).

Kornienko 1
 
Our cancer drug discovery work emphasizes the development of innovative methods to combat apoptosis-resistant cancers, such as melanoma, glioblastoma, lung cancer, among others. Thus, much effort is applied toward the identification and investigation of natural products that exhibit antimetastatic properties at non-toxic concentrations or induce non-apoptotic cancer cell death, such as programmed necrosis, autophagy or paraptosis. We collaborate with a large group of cancer biologists and clinicians in the US and Europe. Examples of natural products, which are currently studied in Dr. Kornienko’s lab, are shown below.
Kornienko2

Representative publications

Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation. Kornienko, A.; La Clair, J. J. Nat. Prod. Rep. 2017, 34, 1051-1060.

Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities. Medellin, D. C.; Zhou, Q.; Scott, R.; Hill, R. M.; Frail, S. K.; Dasari, R.; Ontiveros, S. J.; Pelly, S. C.; van Otterlo, W. A. L.; Betancourt, T. B.; Shuster, C. B.; Hamel, E.; Bai, R.; LaBarbera, D. V.; Rogelj, S.; Frolova, L. V.; Kornienko, A. J. Med. Chem. 2016, 59, 480-485.

Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates Against Drug-Resistant Cancer Cells. Aksenov, A. V.; Smirnov, A. N.; Magedov, I. V.; Reisenaur, M. R.; Aksenov, N. A.; Aksenova, I. V.; Nguyen, G.; Johnston, R. K.; Rubin, M.; Kiss, R.; Mathieu, V.; Lefranc, F.; Correa, J.; Cavazos, D. A.; Brenner, A. J.; Rogelj, S.; Kornienko, A.; Frolova, L. V. J. Med. Chem. 2015, 58, 2206-2220.

Exploring Natural Product Chemistry and Biology with Multicomponent Reactions. 5. Discovery of a Novel Tubulin-Targeting Scaffold Derived from the Rigidin Family of Marine Alkaloids. Frolova, L. V.; Magedov, I. V.; Romero, A. E.; Karki, M.; Otero, I.; Hayden, K.; Evdokimov, N. M.;Banuls L. M. Y.; Rastogi, S. K.; Smith, W. R.; Lu, S. L.; Kiss, R.; Shuster, C. B.; Hamel, E.; Betancourt, T.; Rogelj, S.; Kornienko, A. J. Med. Chem. 2013, 56, 6886.

Perspective: Therapeutic Agents Triggering Non-Apoptotic Cancer Cell Death. Kornienko, A.; Mathieu, V.; Rastogi, S.; Lefranc, F.; Kiss, R. J. Med. Chem. 2013, 56, 4823.

Reengineered Epipodophyllotoxin. Magedov, I. V.; Evdokimov, N. M.; Karki, M.; Peretti, A. S.; Lima, D. T.; Frolova, L.; Reisenauer, M. R.; Romero, A. E.; Tongwa, P.; Fonari, A.; Altig, J.; Rogelj, S.; Antipin, M. Y.; Shuster, C. B.; Kornienko, A. Chem. Commun. 2012, 48, 10416.

Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis. Magedov, I. V.; Frolova, L.; Manpadi, M.; Bhoga, U. D.; Tang, H.; Evdokimov, N. M.; George, O.; Georgiou, K. H.; Renner, S.; Getlic, M.; Kinnibrugh, T. L.; Fernandes, M. A.; van Slambrouck, S.; Steelant, W. F. A.; Shuster, C. B.; Rogelj, S.; van Otterlo, W. A. L.; Kornienko, A. J. Med. Chem. 2011, 54, 4234.