My lab investigates the structural thermodynamics of protein macromolecules to gain molecular descriptions of life and disease pathologies. Currently, three projects are active in my group:
* Structural description of biological activity in intrinsically disordered protein, a protein class that has roles regulating gene expression and has been linked to many diseases, including cancers.
* Development of room-temperature methods to investigate protein cold denaturation and characterize protein structures.
* Molecular interactions that control the self-assembly of protein into nanofibril structures, as a model for certain neurodegenerative disorders.